What Is Petulant BPD? Signs, Causes, and Treatment

You hold it together at work. You're the one who remembers everyone's birthday, because you set four reminders for each. But the effort is constant, the to-do list never shrinks, and by evening there's nothing left. If that sounds familiar, you may be wondering whether ADHD symptoms in women could explain it, especially if no one ever suggested ADHD when you were a child.

ADHD in women often looks different from the hyperactive schoolboy most people picture. It tends to show up as inattention, mental restlessness, emotional overwhelm, and an exhausting amount of compensating. Many women aren't diagnosed until adulthood, after years of being told they're anxious, scattered, or just not trying hard enough.

What ADHD looks like in women

ADHD is a pattern of inattention and/or hyperactivity and impulsivity that makes it hard to function in at least two areas of life, such as home and work. The NIMH describes three types: inattentive, hyperactive-impulsive, and combined.

In girls and women, inattention often dominates. A 2014 review of ADHD in women and girls found that clinicians tend to see girls' symptoms as "subthreshold" because inattentiveness is more prominent than hyperactivity, and that girls may develop stronger coping strategies that mask their symptoms. That combination is a recipe for being overlooked.

It's common, too. In a 2023 national survey, an estimated 15.5 million U.S. adults, about 6.0%, reported a current ADHD diagnosis. Roughly half were diagnosed at 18 or older.

ADHD symptoms in women

ADHD symptoms in women are the same core symptoms anyone with ADHD has. What differs is how they show up and how well they're hidden.

Inattention and mental restlessness

• Losing the thread of conversations, meetings, or what you walked into a room for
• Starting many tasks and finishing few
• Losing keys, phones, and paperwork, then building elaborate systems to compensate
• A busy, noisy mind even when your body is still
• Zoning out during tasks that don't hold your interest

Time, organization, and follow-through

The NIMH notes that adults with ADHD often find it hard to stay organized, keep appointments, and complete large projects. In practice that looks like chronic lateness, piles of half-finished projects, and deadlines met only through last-minute panic.

Emotional intensity

Emotional dysregulation isn't one of the formal diagnostic criteria, but it's part of the picture for many women. An expert consensus statement published in BMC Psychiatry in 2020 noted that difficulties with emotional lability and dysregulation may be more severe or common in girls and women with ADHD. Small frustrations hit hard. Criticism lingers for days. Calming down takes longer than it should.

Impulsivity that's easy to miss

Impulsivity in women often looks less like risk-taking and more like interrupting, oversharing, saying yes to too much, or impulsive spending. It's real impulsivity. It just doesn't get flagged.

What "high-functioning ADHD" means

High-functioning ADHD isn't a diagnosis. You won't find it in the DSM-5. It's an informal way of describing someone whose ADHD symptoms are real and impairing, but hidden behind good grades, a solid job, or a well-run household.

The cost is the part nobody sees. The 2020 consensus statement points to the compensatory strategies that may mask or overshadow ADHD in women: over-preparing, perfectionism, rigid routines, working longer hours than colleagues to produce the same result. Those strategies work, until a new job, a baby, or a parent's illness pushes demands past what they can absorb. That's often when women first seek help.

"High-functioning" can also be misleading. Functioning well in one area doesn't mean functioning well in all of them. A woman can excel at work and still be overwhelmed at home, or keep her household running while her own health slips.

Is it ADD or ADHD?

"ADD" is an older, informal name that many people still use, especially for ADHD without obvious hyperactivity. Clinicians now use ADHD for all three types. What people usually mean by "ADD symptoms in women" is the inattentive type of ADHD: trouble focusing, organizing, and following through, without much visible restlessness.

Why ADHD in women gets missed

There are a few overlapping reasons:

• Quieter symptoms. Inattention is less disruptive than hyperactivity, so teachers and parents are less likely to refer a girl for evaluation.
• Masking. Coping strategies hide symptoms, sometimes from the woman herself.
• Other diagnoses first. The NIMH notes that ADHD often co-occurs with anxiety and depression, which can make each condition harder to diagnose and treat. Many women are treated for anxiety or depression for years before anyone considers ADHD. (We've written about how anxiety and depression overlap.)

The NIMH puts it plainly: ADHD symptoms in girls and women are especially likely to have been missed in childhood, and sex differences in diagnosis rates start to even out in adulthood. A 2023 systematic review in the Journal of Attention Disorders of women diagnosed as adults found recurring themes of strain on emotional wellbeing, difficult relationships, a sense of lack of control, and, after diagnosis, self-acceptance. For more on how presentations differ, see ADHD in women vs. men.

Hormones and ADHD symptoms

Many women notice their ADHD symptoms change across the month or at different life stages. Research is starting to catch up. A 2025 systematic review of 11 studies found evidence suggesting a link between sex hormones and ADHD symptoms in females, particularly during puberty and across the menstrual cycle. The authors called the evidence limited, with small samples, and noted that menopause has barely been studied.

If your symptoms seem to shift before your period or during perimenopause, you're not imagining it. Research just hasn't mapped those patterns well yet, so a symptom log gives a clinician more to work with than the studies do.

How ADHD is diagnosed in adults

There's no blood test or brain scan for ADHD. According to the NIMH, a diagnosis in adulthood requires:

• Symptoms that started before age 12, which is why clinicians ask about childhood and may want to talk to family members or see old school reports
• At least five symptoms of inattention or of hyperactivity and impulsivity (adults and teens over 16 need five, children six)
• Symptoms that cause problems in at least two areas of life

A careful evaluation also looks for conditions that mimic or accompany ADHD, especially anxiety, depression, sleep problems, and mood disorders. That step matters for women, who are more likely to arrive with one of those diagnoses already in their chart.

Treatment for ADHD in women

The most common treatments for adult ADHD, according to the NIMH, are medication (usually stimulants) and psychotherapy such as behavioral and cognitive behavioral therapy. Effective treatment often combines both, and some people need to try more than one approach. ADHD coaching can help with executive-function skills like planning and time management.

When ADHD comes with depression, anxiety, or bipolar disorder

For many women, ADHD isn't the whole story. It's the overlooked layer beneath years of depression, anxiety, or mood instability. When those conditions are severe or keep coming back despite treatment, getting the full picture right matters more than any single diagnosis.

At Amae Health, we treat complex mental health conditions, including Major Depressive Disorder and Bipolar Disorder, in integrated outpatient clinics. Our care teams bring psychiatrists, therapists, primary care physicians, and care coordinators under one roof, so a co-occurring condition like ADHD is considered as part of one treatment plan rather than in isolation. See how our integrated outpatient clinics work.

Frequently asked questions

What are the first signs of ADHD in women?

Common early signs include chronic disorganization, losing things, trouble finishing tasks, a restless mind, and feeling far more exhausted by everyday demands than peers seem to be. Many women recognize these patterns only in hindsight, often after a child is diagnosed or life demands increase.

Can you have ADHD and still be successful?

Yes. Many women with ADHD do well in school and work, often by compensating with extra effort, structure, and perfectionism. Success doesn't rule out ADHD. A clinician looks at impairment across areas of life and at how much effort functioning takes.

Is it ADHD or anxiety?

They can look alike and often occur together. Anxiety centers on worry and fear. ADHD centers on attention, organization, and impulsivity that have been present since childhood. Some women have both, and an evaluation should consider each.

Does ADHD get worse during perimenopause?

Some women notice that it does, and early research suggests hormones can affect ADHD symptoms. But studies on menopause are still very limited, so it isn't yet clear how common or predictable the change is.

How do I get tested for ADHD as an adult woman?

Start with a primary care provider or a psychiatrist who evaluates adults. Expect questions about childhood, current symptoms, and other conditions. Bringing old school reports or a family member who knew you as a child can help.

Key takeaways

• ADHD symptoms in women often center on inattention, mental restlessness, emotional intensity, and disorganization, rather than visible hyperactivity.
• "High-functioning ADHD" and "ADD" are informal terms. The diagnosis is ADHD, with three types.
• Masking and co-occurring anxiety or depression are two common reasons ADHD in women goes undiagnosed until adulthood.
• Diagnosis requires symptoms that began before age 12. Treatment usually combines medication, therapy, and skills support.

If ADHD has been sitting underneath depression, anxiety, or mood swings that haven't improved, you don't have to keep sorting through it alone. Request an intake appointment, and our team will explain how an evaluation works and what your first visit includes.

It starts small. A comment, a delay, a tone of voice. Then, before you can stop it, you're yelling, crying, or shaking, and afterward you're left with the cleanup and the shame. If emotional outbursts keep happening and you can't predict or stop them, you're probably wondering why, and what you can do about it.

An emotional outburst is a sudden, intense expression of emotion, usually anger, crying, or panic, that feels out of proportion to the moment and hard to control. Occasional outbursts under heavy stress are part of being human. Frequent or escalating ones are often a sign that something underneath needs attention, such as exhaustion, unresolved stress, or a mental health condition that affects emotional regulation.

What emotional outbursts look like

Outbursts look different from person to person, but common forms include:

• Sudden anger, yelling, or slamming things
• Crying that comes on fast and is hard to stop
• Panic, with a racing heart, shaking, or trouble breathing
• Saying things you don't mean and regret afterward
• Shutting down or storming out
• Feeling flooded, unable to think clearly until the wave passes

Many people describe feeling like a passenger: they can see the outburst happening but can't steer it.

Why emotional outbursts happen

Everyday drivers

Before looking at diagnoses, check the basics. Lack of sleep, hunger, physical pain, ongoing stress at work or home, and alcohol all lower the threshold for losing control. So does carrying unspoken frustration for a long time. These factors don't excuse outbursts, but they're often the easiest to change.

Mental health conditions linked to emotional outbursts

When outbursts are frequent, intense, or out of character, they're often part of a condition that affects how emotions are regulated.

• Borderline personality disorder (BPD). The NIMH describes BPD as involving difficulty regulating emotions, intense and highly variable moods lasting from a few hours to a few days, and inappropriate, intense anger or problems controlling anger.
• Bipolar disorder. During manic or mixed episodes, the NIMH lists feeling extremely irritable or touchy among the symptoms, and mood can shift sharply. Our bipolar disorder treatment page covers how this is treated.
• Depression. Depression isn't only sadness. The NIMH lists irritability, frustration, and restlessness among its common symptoms.
• PTSD. The NIMH lists feeling irritable and having angry or aggressive outbursts among the arousal and reactivity symptoms of PTSD, along with being easily startled and feeling on edge.
• ADHD. Emotional regulation isn't part of the formal ADHD criteria, but a review in the American Journal of Psychiatry found that emotion dysregulation is common in ADHD across the lifespan and is a major contributor to impairment.

Neurological causes of sudden crying or laughing

Sometimes "random emotional outbursts" have a neurological cause. Pseudobulbar affect (PBA) causes sudden, involuntary episodes of crying or laughing that don't match how a person actually feels. According to a 2022 systematic review and meta-analysis, it's associated with conditions including traumatic brain injury, multiple sclerosis, ALS, stroke, Parkinson's disease, and dementia. If outbursts of crying or laughing started after a brain injury or alongside a neurological diagnosis, a neurologist should know about them.

What to do in the moment

When you feel an outburst building, the goal isn't to suppress the emotion. It's to buy enough time for your thinking brain to catch up.

• Name it. Saying, even silently, "I'm getting overwhelmed" creates a small gap between feeling and acting.
• Slow your breathing. Breathe out longer than you breathe in. Repeat for a minute or two.
• Take a planned break. Tell the other person you need ten minutes and will come back. Then actually come back.
• Ground yourself. Notice five things you can see, four you can touch, three you can hear.
• Move. A short walk or a few stretches can burn off some of the physical charge.
• Delay decisions. Don't send the message, quit the job, or end the relationship in the middle of the wave.

None of these is a cure. They're tools to stop an outburst from becoming a crisis.

What helps long term

Treating the underlying condition

If outbursts are part of depression, bipolar disorder, PTSD, BPD, or ADHD, treating that condition is usually what reduces them most. That might involve therapy, medication, or both, chosen by a clinician who understands the full picture.

Therapy for emotional regulation

Dialectical behavior therapy (DBT) was developed specifically for BPD and teaches skills for intense emotions, distress tolerance, and relationships. Those skills are useful well beyond BPD. A 2020 Cochrane review of 75 trials found that psychotherapy reduced BPD symptom severity compared with usual care, with DBT and mentalization-based treatment the most studied. Cognitive behavioral therapy (CBT) can also help people recognize triggers and the thoughts that escalate them.

The basics, done consistently

Regular sleep, limiting alcohol, physical activity, and having at least one person you can talk to don't fix a mental health condition. They do lower the baseline level of stress that outbursts grow from.

When to get help

Talk to a mental health professional if outbursts are frequent, are getting worse, are damaging relationships or work, or come with mood swings, depression, or trauma symptoms. Get help urgently if outbursts involve violence, threats, or self-harm. If anyone is in immediate danger, call 911. If there are thoughts of suicide, call or text 988.

At Amae Health, our clinics specialize in conditions where emotional outbursts are often part of the picture, including Borderline Personality Disorder, bipolar disorder, and Major Depressive Disorder. Our care teams bring psychiatrists, therapists, primary care physicians, peer mentors, and care coordinators under one roof, working from one treatment plan. We've also written about related patterns in quiet BPD and petulant BPD.

Supporting someone who has emotional outbursts

• Stay as calm as you can, and keep your voice low and steady.
• Don't try to reason through the peak. Wait until things settle to talk.
• Set clear limits on behavior you won't accept, such as yelling at you or breaking things.
• Talk about patterns later, when you're both calm.
• Encourage an evaluation if outbursts are frequent or getting worse.
• Take care of yourself too. Supporting someone through this is hard. Our guide on how to help someone with mental health issues has more.

Frequently asked questions

Why do I have random emotional outbursts?

Common reasons include stress, poor sleep, and conditions such as depression, bipolar disorder, BPD, PTSD, and ADHD. In some people, sudden crying or laughing that doesn't match their mood is caused by a neurological condition called pseudobulbar affect.

Are emotional outbursts a sign of a mental illness?

Not always. Occasional outbursts under heavy stress are common. Frequent, intense, or escalating outbursts deserve an evaluation, because they're often linked to a treatable condition.

How do I stop emotional outbursts?

In the moment, name what's happening, slow your breathing, and take a planned break. Long term, treating any underlying condition and learning emotional regulation skills, such as those taught in DBT, are what make lasting change.

What is emotional volatility?

Emotional volatility describes emotions that shift quickly and intensely. It's a feature of several conditions, including BPD and bipolar disorder, and can also come from stress, exhaustion, or substance use.

Key takeaways

• Emotional outbursts are sudden, intense, and hard to control. Frequent ones usually have a cause that can be addressed.
• Conditions linked to outbursts include BPD, bipolar disorder, depression, PTSD, and ADHD. Sudden crying or laughing can also have a neurological cause.
• In-the-moment tools buy time. Treating the underlying condition and learning regulation skills make lasting change.
• Get urgent help if outbursts involve violence, threats, or self-harm.

If emotional outbursts are part of a bigger pattern of mood swings, depression, or unstable relationships, for you or someone you love, request an intake appointment. Our team will explain how an evaluation works and what the first visit involves.

If you are comparing TMS, ketamine, and Spravato for depression, you have probably reached the point where standard antidepressants have not done enough. All three are evidence-based options for treatment-resistant depression, and beyond that they have little in common. TMS is a course of magnetic stimulation delivered while you sit awake in a chair. Ketamine is an anesthetic given by IV, used off-label for depression. Spravato is a nasal spray made from esketamine, one of the two mirror-image forms that make up ketamine, with its own FDA approval and its own rulebook.

‍

None of the three is universally better. They differ in mechanism, speed, setting, and monitoring, and the right one depends on your clinical history and how you respond. Treatment-resistant depression generally means depression that has not adequately improved after at least two antidepressants taken at a proper dose for long enough, and that is the group where all three are most often used.

What Is TMS?

Transcranial magnetic stimulation uses a coil placed against the scalp to deliver focused magnetic pulses to the left dorsolateral prefrontal cortex, a region involved in mood regulation. The FDA first cleared TMS for major depressive disorder in 2008, according to the National Institute of Mental Health. It is delivered in an office, with no anesthesia and no medication.

‍

Our standard TMS course runs 20 to 30 daily sessions over four to six weeks, each 30 to 40 minutes long. You stay awake throughout and drive yourself home afterward. In real-world outcome data from 42 U.S. practices, more than half of patients with medication-resistant depression responded to a standard course, and more than a third reached remission.

What Is Ketamine Therapy?

Ketamine has been an FDA-approved anesthetic since 1970. Its use for depression is off-label: prescribed for a purpose the FDA has not formally approved, which is legal and common in medicine but leaves the safeguards less standardized. It is usually given as an IV infusion in a monitored clinic, as a series of sessions over a few weeks.

‍

Ketamine blocks the NMDA receptor, a glutamate receptor, rather than acting on serotonin like standard antidepressants, and that difference is thought to explain its speed. In a landmark 2006 trial, 18 people with treatment-resistant depression received a single infusion of 0.5 mg/kg, and their symptoms improved significantly within 110 minutes. By the next day, 71% had responded and 29% were in remission. One week later, 35% still met the response threshold. Rapid, real, and often short-lived.

‍

The catch is in the monitoring. Ketamine causes dissociation, a sense of detachment from your body or surroundings, plus sedation and blood pressure rises during and after the infusion, so you are observed until those effects pass and cannot drive that day. In a 2017 consensus statement in JAMA Psychiatry, an American Psychiatric Association task force found the evidence for rapid antidepressant effects convincing but the studies small, the longer-term efficacy data lacking, and the safety data on repeated dosing limited.

What Is Spravato (Esketamine)?

Ketamine is a mixture of two mirror-image molecules. Spravato is esketamine, one of those two, delivered as a nasal spray. Unlike IV ketamine, it has FDA approval for depression. The original approval came in March 2019 for treatment-resistant depression alongside an oral antidepressant, a second indication followed for adults with major depressive disorder and acute suicidal thoughts or behavior, and in January 2025 the FDA approved Spravato as a standalone monotherapy for treatment-resistant depression, with no oral antidepressant required, per the current prescribing information.

‍

That approval comes with a rulebook. Spravato can only be given at a setting certified under a Risk Evaluation and Mitigation Strategy (REMS) program: you take the spray under supervision, you are monitored for at least two hours before an assessment clears you to leave, and you cannot drive until the next day after a restful sleep. Its label carries a boxed warning for sedation, dissociation, respiratory depression, abuse and misuse, and suicidal thoughts and behaviors in younger patients.

‍

So is Spravato the same as ketamine? Related, not identical: same molecular family, same receptor, similar rapid onset and dissociative effects, but a different route, a formal FDA indication, and mandatory monitoring rules that off-label ketamine does not carry. For most people comparing TMS vs Spravato, those rules and insurance coverage are the practical differences that matter.

TMS vs Ketamine vs Spravato: Side-by-Side Comparison

Onset and Duration of Effect

Speed is the clearest dividing line. TMS builds gradually, and many people do not notice a clear change until the second or third week or later. Ketamine and Spravato can shift symptoms within hours to days.

‍

Speed and staying power are different things. Ketamine's effect after a single infusion often fades within a week or two, which is why it is given as a series with maintenance dosing. Spravato starts at twice a week and tapers, with the need for continued treatment reassessed along the way. Research on durability is still developing for all three, and none should be described as permanent.

Side Effects and Safety Considerations

TMS side effects are local and short-lived: scalp discomfort where the coil sits, headache, and sometimes brief lightheadedness or facial muscle twitching during the pulses. These usually settle within the first week, and because nothing enters the bloodstream there is no weight gain, sexual dysfunction, or sedation. Seizure is the one serious risk, exceedingly rare, and TMS is not used in people with a seizure history, metal in the head, or implanted electronic devices.

‍

Ketamine and Spravato share a different profile. The most common reactions to Spravato in trials were dissociation, dizziness, nausea, sedation, vertigo, numbness, anxiety, lethargy, increased blood pressure, vomiting, feeling drunk, and headache. Those effects peak in the hours after dosing, which is what the monitoring window is for, and both drugs carry a potential for misuse that shapes who is a candidate. Each option has its own screening, and a contraindication to one does not rule out the others.

Cost and Insurance

For TMS, most commercial insurers cover treatment for major depressive disorder once eligibility criteria are met, typically a confirmed diagnosis and documented antidepressant trials without adequate relief. Prior authorization is standard. For TMS we take all commercial insurance plans, cash pay is available, and authorization is something our intake team manages for you.

‍

Spravato is more commonly covered than off-label ketamine because it has an FDA indication insurers can write criteria around, though prior authorization and documentation of failed antidepressant trials are typically required. Ketamine infusion coverage varies widely, and many clinics are self-pay. Published cost estimates vary so much by dose, frequency, and insurance status that a single dollar figure would mislead; ask each provider and your insurer directly.

Can These Treatments Be Combined?

Sometimes, and the research is early. A 2024 systematic review found six published studies on combining TMS with ketamine, mostly case reports plus one retrospective review and one small pilot, and reported substantial and sustained improvement with generally mild side effects. The authors also said the designs were too varied and the samples too small for firm conclusions, and called for randomized trials.

‍

In practice, TMS and Spravato are sometimes used one after the other. Combining any of these is a clinical judgment a psychiatrist makes from your history, not a general recommendation, and the more common pattern is to use one, assess the response, then decide.

Choosing Between Them: What Influences the Decision

A psychiatrist weighing these options usually works through a short list:

‍

• Treatment history. Which antidepressants, at what doses, for how long, and whether psychotherapy has been tried.
• How urgently relief is needed. When symptoms are severe or suicidal thoughts are present, a faster-acting option may take priority, alongside care for suicidal thoughts.
• Tolerance for the experience. Dissociation and a two-hour monitored window, versus a daily half-hour appointment for several weeks with no drug effects.
• Practical constraints. Whether you can get to daily sessions, whether someone can drive you home after Spravato or ketamine, and what your insurance will authorize.
• Health factors. Seizure history, metal implants, blood pressure, and any history of substance misuse each rule options in or out.
• What else is in place. Any of the three works better inside ongoing psychiatric care and therapy than as a standalone fix.

Making the Decision With an Integrated Care Team

TMS, ketamine, and Spravato are tools, and tools do their best work inside a plan: a psychiatrist who knows your history, a therapist working alongside the biological treatment, and a team that notices when the plan needs to change.

‍

That is how we work. At Amae, our one-team care model combines psychiatry, therapy, primary care, and peer support, and TMS and Spravato are available through our Los Angeles and Bay Area clinics as part of that care. If you have been through the antidepressant cycle and want a clear, unhurried look at what comes next, talk with an Amae psychiatrist about your options. If you are in crisis or thinking about suicide, call or text 988 now.

Frequently Asked Questions

What is the difference between TMS and ketamine for depression?

TMS stimulates the brain with magnetic pulses over a course of daily outpatient sessions, with no drug, no sedation, and no monitoring afterward. Ketamine is a medication that acts on NMDA receptors, given by infusion or, as esketamine, by nasal spray, with monitored sedation and dissociation and often faster but shorter-lived effects.

Is Spravato the same as ketamine?

Related but not identical. Spravato is esketamine, the S-enantiomer of the ketamine molecule, delivered as an FDA-approved nasal spray under a required monitoring program. Ketamine infusions use the full ketamine compound and are prescribed off-label for depression, without an FDA indication for that use.

Is Spravato only approved with an antidepressant?

Not anymore. The original 2019 approval was for use alongside an oral antidepressant, and in January 2025 the FDA also approved Spravato as a standalone monotherapy for adults with treatment-resistant depression. Whether it is used alone or with an antidepressant is a decision your psychiatrist makes based on your situation.

Which works faster, TMS or Spravato?

Spravato. Esketamine and ketamine can produce symptom change within hours to days, while TMS builds gradually across a four-to-six-week course. Faster onset does not mean more durable improvement, and both durability and side effects belong in the comparison.

Can TMS and Spravato be used together?

Sometimes, as a clinical decision made with a psychiatrist based on your individual history. Both can be part of a broader treatment-resistant depression plan alongside medication and therapy, and the evidence on combining them is still early.

Is ketamine or Spravato covered by insurance?

Spravato is more commonly covered, because it has an FDA indication insurers can build criteria around, though prior authorization and proof of failed antidepressant trials are usually required. Coverage for off-label ketamine infusions varies widely and is often self-pay. Confirm with the provider and your insurer before starting.

‍

Citations

1. National Institute of Mental Health. Brain Stimulation Therapies. https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies
2. Carpenter LL, Janicak PG, Aaronson ST, et al. Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice. Depression and Anxiety. 2012. https://pubmed.ncbi.nlm.nih.gov/22689344/
3. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry. 2006. https://pubmed.ncbi.nlm.nih.gov/16894061/
4. Sanacora G, Frye MA, McDonald W, et al. A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry. 2017. https://pubmed.ncbi.nlm.nih.gov/28249076/
5. U.S. Food and Drug Administration. Drugs@FDA: SPRAVATO (esketamine), NDA 211243, approval history. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=211243
6. U.S. Food and Drug Administration. SPRAVATO (esketamine) nasal spray prescribing information, revised January 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/211243s016lbl.pdf
7. Arubuolawe OO, Folorunsho IL, Busari AK, et al. Combination of transcranial magnetic stimulation and ketamine in treatment-resistant depression: a systematic review. Cureus. 2024. https://pubmed.ncbi.nlm.nih.gov/39156335/
8. 988 Suicide and Crisis Lifeline. https://988lifeline.org

‍